JAM-A regulates epithelial proliferation through Akt/β-catenin signalling.

@article{Nava2011JAMARE,
  title={JAM-A regulates epithelial proliferation through Akt/β-catenin signalling.},
  author={Porfirio Nava and Christopher T. Capaldo and Stefan Koch and Keli N. Kolegraff and Carl Robert Rankin and Attila E. Farkas and Mattie E Feasel and Linheng Li and Caroline Addis and Charles A Parkos and Asma Nusrat},
  journal={EMBO reports},
  year={2011},
  volume={12 4},
  pages={314-20}
}
Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts intestinal epithelial cell (IEC… CONTINUE READING