JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.

@article{Nishiya2015JAK3IV,
  title={JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.},
  author={Naoyuki Nishiya and Yasumitsu Sakamoto and Yusuke Oku and Takamasa Nonaka and Yoshimasa Uehara},
  journal={World journal of biological chemistry},
  year={2015},
  volume={6 4},
  pages={409-18}
}
AIM To identify non-quinazoline kinase inhibitors effective against drug resistant mutants of epidermal growth factor receptor (EGFR). METHODS A kinase inhibitor library was subjected to screening for specific inhibition pertaining to the in vitro kinase activation of EGFR with the gatekeeper mutation T790M, which is resistant to small molecular weight… CONTINUE READING