JAK2V617F negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms

@article{Nakatake2012JAK2V617FNR,
  title={JAK2V617F negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms},
  author={Mayuka Nakatake and B{\'a}rbara da Costa Reis Monte-M{\'o}r and Najet Debili and Nicole Casadevall and Vincent Ribrag and {\'E}ric Solary and William Vainchenker and Isabelle Plo},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={1323-1333}
}
JAK2V617F is a gain of function mutation that promotes cytokine-independent growth of myeloid cells and accounts for a majority of myeloproliferative neoplasms (MPN). Mutations in p53 are rarely found in these diseases before acute leukemia transformation, but this does not rule out a role for p53 deregulation in disease progression. Using Ba/F3-EPOR cells and ex vivo cultured CD34+ cells from MPN patients, we demonstrate that expression of JAK2V617F affected the p53 response to DNA damage. We… CONTINUE READING