JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

@article{Lacout2006JAK2V617FEI,
  title={JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.},
  author={Catherine Lacout and Didier F Pisani and Micheline Tulliez and Françoise Moreau Gachelin and William Vainchenker and J L Villeval},
  journal={Blood},
  year={2006},
  volume={108 5},
  pages={1652-60}
}
A JAK2(V617F) mutation is frequently found in several BCR/ABL-negative myeloproliferative disorders. To address the contribution of this mutant to the pathogenesis of these different myeloproliferative disorders, we used an adoptive transfer of marrow cells transduced with a retrovirus expressing JAK2(V617F) in recipient irradiated mice. Hosts were analyzed during the 6 months after transplantation. For a period of 3 months, mice developed polycythemia, macrocytosis and usually peripheral blood… CONTINUE READING