JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.

@article{Weiler1996JAK2IA,
  title={JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.},
  author={Sara R. Weiler and Sherry Mou and C S Deberry and Jonathan R. Keller and Francis W. Ruscetti and Douglas K. Ferris and Dan L. Longo and Diana Linnekin},
  journal={Blood},
  year={1996},
  volume={87 9},
  pages={3688-93}
}
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2 in human and murine cell lines, as well as in normal human progenitor cells. JAK2 and c-kit were associated in unstimulated cells with further recruitment of JAK2 to the c-kit receptor complex after SCF stimulation. Treatment of cells with JAK2 antisense oligonucleotides resulted in a 46% decrease… CONTINUE READING

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