JAK2 is an important signal transducer in IL-33-induced NF-κB activation.

@article{FunakoshiTago2011JAK2IA,
  title={JAK2 is an important signal transducer in IL-33-induced NF-κB activation.},
  author={Megumi Funakoshi-Tago and Kenji Tago and Yoshinori Sato and Shin-ichi Tominaga and Tadashi Kasahara},
  journal={Cellular signalling},
  year={2011},
  volume={23 2},
  pages={363-70}
}
IL-33, a member of the IL-1 family of cytokines, has been shown to activate NF-κB and MAP kinase family through the IL-1 receptor-related protein, ST2L. In this study, we found that IL-33 rapidly activated a tyrosine kinase, JAK2. Interestingly, we demonstrated the functional involvement of JAK2 in IL-33-induced IκBα degradation and NF-κB activation, since a JAK2 inhibitor, AG490, effectively inhibited this signaling pathway. Furthermore, IL-33 failed to induce IκBα degradation and NF-κB… CONTINUE READING