JAK2 V617F, hemostatic polymorphisms, and clinical features as risk factors for arterial thrombotic events in essential thrombocythemia

@article{Moreno2008JAK2VH,
  title={JAK2 V617F, hemostatic polymorphisms, and clinical features as risk factors for arterial thrombotic events in essential thrombocythemia},
  author={Mar{\'i}a Jos{\'e} Donate Moreno and Mar{\'i}a Luisa Lozano and Vanessa Rold{\'a}n and Beatriz Bellosillo and Nuria Garc{\'i}a-Barber{\'a} and Jennifer E Rivera and Leyre Navarro-N{\'u}{\~n}ez and Carlos Besses and Vicente Vicente and Clara Martinez},
  journal={Annals of Hematology},
  year={2008},
  volume={87},
  pages={763-765}
}
Dear Editor, A recentmutation located in the JAK2 gene, JAK2 V617F, has been shown to play a transcendental role in the constitutive activation of its tyrosine kinase activity in an important number of cases of Philadelphia negative myeloproliferative disorders (Ph-MPDs). This mutation is a useful tool for diagnosing this diseases because different studies… CONTINUE READING