JAK mutations in high-risk childhood acute lymphoblastic leukemia.

  title={JAK mutations in high-risk childhood acute lymphoblastic leukemia.},
  author={Charles G Mullighan and Jinghui Zhang and Richard C Harvey and J. Racquel Collins-Underwood and Brenda A. Schulman and Letha A A Phillips and Sarah K Tasian and Mignon L Loh and Xiaoping Su and Wei Liu and Meenakshi Devidas and Susan R. Atlas and I-Ming Chen and Robert J. Clifford and Daniela S. Gerhard and William L Carroll and Gregory H. Reaman and Malcolm A Smith and James R. Downing and Stephen P Hunger and Cheryl L. Willman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 23},
Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations. Mutation of genes encoding tyrosine kinases is uncommon in ALL, with the exception of Philadelphia chromosome-positive ALL, where the t(9,22)(q34;q11) translocation encodes the constitutively active BCR-ABL1 tyrosine kinase. We recently identified a poor prognostic subgroup of pediatric BCR… CONTINUE READING
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