JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical.


Rheumatoid arthritis (RA) is a representative autoimmune disease characterized by chronic and destructive inflammatory synovitis. The multiple cytokines play pivotal roles in RA pathogenesis by inducing intracellular signaling, and members of the Janus kinase (JAK) family are essential for such signal transduction. An orally available JAK3 inhibitor… (More)
DOI: 10.1007/s10165-012-0799-2


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