JAK-STAT3 and somatic cell reprogramming

  title={JAK-STAT3 and somatic cell reprogramming},
  author={Yong Tang and Xiuchun Tian},
Reprogramming somatic cells to pluripotency, especially by the induced pluripotent stem cell (iPSC) technology, has become widely used today to generate various types of stem cells for research and for regenerative medicine. However the mechanism(s) of reprogramming still need detailed elucidation, including the roles played by the leukemia inhibitory factor (LIF) signaling pathway. LIF is central in maintaining the ground state pluripotency of mouse embryonic stem cells (ESCs) and iPSCs by… CONTINUE READING


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