JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells.

@article{Liu2010JAKSTATIR,
  title={JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells.},
  author={Wei Liu and Shree Ram Singh and Steven X. Hou},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={109 5},
  pages={992-9}
}
The Drosophila midgut epithelium undergoes continuous regeneration that is sustained by multipotent intestinal stem cells (ISCs) underneath. Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ISCs into different differentiation pathways at a dose-dependent manner. Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is… CONTINUE READING

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