JAK-STAT and bone metabolism
@article{Li2013JAKSTATAB, title={JAK-STAT and bone metabolism}, author={J. Li}, journal={JAK-STAT}, year={2013}, volume={2} }
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which… CONTINUE READING
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References
SHOWING 1-10 OF 86 REFERENCES
Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species.
- Chemistry, Medicine
- Bone
- 2011
- 65
Inhibition of STAT1 accelerates bone fracture healing
- Chemistry, Medicine
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- 2010
- 34
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.
- Biology, Medicine
- Genes & development
- 2003
- 226
- PDF
A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.
- Biology, Medicine
- Bone
- 2006
- 138
Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
- Chemistry, Medicine
- The Journal of clinical investigation
- 2004
- 167
- PDF
Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells.
- Biology, Medicine
- Endocrinology
- 1996
- 49
- PDF
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
- Biology, Medicine
- Oncogene
- 2000
- 1,056
- PDF
Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation.
- Biology, Medicine
- Endocrinology
- 1997
- 189
- PDF
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
- Biology, Medicine
- Cell
- 1998
- 1,320