• DOI:10.4161/jkst.23930
Corpus ID: 14797647

JAK-STAT and bone metabolism

@article{Li2013JAKSTATAB,
  title={JAK-STAT and bone metabolism},
  author={J. Li},
  journal={JAK-STAT},
  year={2013},
  volume={2}
}

J. Li

Published 2013

Medicine

JAK-STAT

Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which… CONTINUE READING

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