JAK-STAT and bone metabolism

  title={JAK-STAT and bone metabolism},
  author={J. Li},
  • J. Li
  • Published 2013
  • Medicine
  • Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which… CONTINUE READING
    65 Citations
    JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration
    • PDF
    JAK/STAT pathway and molecular mechanism in bone remodeling
    • PDF
    Janus kinase inhibitors role in bone remodeling
    • 3
    • Highly Influenced
    STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription
    • 10
    • PDF
    JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function
    • 9
    STAT3 promotes bone fracture healing by enhancing the FOXP3 expression and the suppressive function of regulatory T cells
    • G. Sun, Zhen Wang, +4 authors H. Qian
    • Medicine
    • APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
    • 2017
    • 8
    MicroRNA-17 Targets JAK1 and STAT3 to Inhibit Osteoblast Differentiation
    • Highly Influenced
    • PDF
    Osteoimmunology in rheumatoid and psoriatic arthritis: potential effects of tofacitinib on bone involvement
    • 2
    • PDF
    Mechanotransduction pathways in bone pathobiology.
    • 24
    Stat3 in osteocytes mediates osteogenic response to loading
    • 9


    Inhibition of STAT1 accelerates bone fracture healing
    • K. Tajima, H. Takaishi, +12 authors Y. Toyama
    • Chemistry, Medicine
    • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
    • 2010
    • 34
    Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
    • 167
    • PDF
    Defective Lymphoid Development in Mice Lacking Jak3
    • 660