JAK-STAT and bone metabolism

@article{Li2013JAKSTATAB,
  title={JAK-STAT and bone metabolism},
  author={J. Li},
  journal={JAK-STAT},
  year={2013},
  volume={2}
}
  • J. Li
  • Published 2013
  • Medicine
  • JAK-STAT
  • Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which… CONTINUE READING
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    References

    SHOWING 1-10 OF 86 REFERENCES
    Inhibition of STAT1 accelerates bone fracture healing
    • K. Tajima, H. Takaishi, +12 authors Y. Toyama
    • Chemistry, Medicine
    • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
    • 2010
    • 34
    Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
    • 167
    • PDF
    Defective Lymphoid Development in Mice Lacking Jak3
    • 660