JAK–STAT and JAK–PI3K–mTORC1 Pathways Regulate Telomerase Transcriptionally and Posttranslationally in ATL Cells

@article{Yamada2012JAKSTATAJ,
  title={JAK–STAT and JAK–PI3K–mTORC1 Pathways Regulate Telomerase Transcriptionally and Posttranslationally in ATL Cells},
  author={O. Yamada and K. Ozaki and M. Akiyama and K. Kawauchi},
  journal={Molecular Cancer Therapeutics},
  year={2012},
  volume={11},
  pages={1112 - 1121}
}
  • O. Yamada, K. Ozaki, +1 author K. Kawauchi
  • Published 2012
  • Biology, Medicine
  • Molecular Cancer Therapeutics
  • Adult T-cell leukemia (ATL) is a heterogeneous tumor that is resistant to chemotherapy. Telomerase activity plays a critical role in tumorigenesis and is associated with the prognosis of ATL patients. Interleukin (IL)-2 commonly promotes tumor growth in chronic ATL cells. The signaling pathways involved in IL-2–regulated telomerase activation were studied in ATL cells derived from chronic ATL patients. IL-2 challenge enhanced tyrosine phosphorylation of Janus-activated kinase (JAK)1–3 and STAT5… CONTINUE READING
    38 Citations
    Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia
    • 10
    The Role of E3 Ubiquitin Ligase Cbl Proteins in Interleukin-2-Induced Jurkat T-Cell Activation
    • 7
    • PDF
    Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
    • 75
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 38 REFERENCES
    Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.
    • 281
    • PDF
    Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells.
    • 46
    Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.
    • 112
    • PDF
    Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1.
    • 30
    Inactivation of hTERT transcription by Tax
    • 87
    • PDF
    Multistep regulation of telomerase during differentiation of HL60 cells
    • 23
    Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils
    • 67
    • PDF
    IL‐2 withdrawal induces HTLV‐1 expression through p38 activation in ATL cell lines
    • 9
    • PDF