JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.

@article{Bltke2013JAKSTATSE,
  title={JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.},
  author={Mary Ann Bl{\"a}tke and Anna Dittrich and Christian Rohr and Monika Heiner and Fred Schaper and Wolfgang Marwan},
  journal={Molecular bioSystems},
  year={2013},
  volume={9 6},
  pages={
          1290-307
        }
}
Mathematical models of molecular networks regulating biological processes in cells or organisms are most frequently designed as sets of ordinary differential equations. Various modularisation methods have been applied to reduce the complexity of models, to analyse their structural properties, to separate biological processes, or to reuse model parts. Taking the JAK/STAT signalling pathway with the extensive combinatorial cross-talk of its components as a case study, we make a natural approach… 
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