JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI.

@article{Raible2015JAKSTATPR,
  title={JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI.},
  author={Daniel J Raible and L Chemnitz Frey and Yasmin Cruz Del Angel and Jessica Carlsen and Dana K Hund and Shelley J. Russek and Bret N Smith and Amy R Brooks-Kayal},
  journal={Experimental neurology},
  year={2015},
  volume={271},
  pages={445-56}
}
Synaptic inhibition in the adult brain is primarily mediated by the γ-aminobutyric acid (GABA) type A receptor (GABA(A)R). The distribution, properties, and dynamics of these receptors are largely determined by their subunit composition. Alteration of subunit composition after a traumatic brain injury (TBI) may result in abnormal increased synaptic firing and possibly contribute to injury-related pathology. Several studies have shown that the Janus Kinase/Signal Transducer and Activator of… CONTINUE READING