JAAD Grand Rounds quiz. Pruritic, recurrent, erythematous plaques.

a t(17;22) chromosomal translocation linking the collagen 1A1 (COL1A1) gene from chromosome 17 with the platelet-derived growth factor beta (PDGFb) gene from chromosome 22. This translocation allows the PDGFb receptor tyrosine kinase to become constitutively active, leading to the proliferation of spindle cells seen in this disease. This mutation also… (More)