Ixodid tick salivary gland extracts suppress human transforming growth factor-β1 triggered signalling pathways in cervical carcinoma cells

@article{Holkov2018IxodidTS,
  title={Ixodid tick salivary gland extracts suppress human transforming growth factor-β1 triggered signalling pathways in cervical carcinoma cells},
  author={Viera Hol{\'i}kov{\'a} and Iveta {\vS}tibr{\'a}niov{\'a} and Pavl{\'i}na Bart{\'i}kov{\'a} and Mirko Slov{\'a}k and M{\'a}ria Kazim{\'i}rov{\'a}},
  journal={Biologia},
  year={2018},
  volume={73},
  pages={1109-1122}
}
  • Viera Holíková, Iveta Štibrániová, +2 authors Mária Kazimírová
  • Published in Biologia 2018
  • DOI:10.2478/s11756-018-0129-z
Ticks, very successful vectors and reservoirs of diverse viruses and other infectious agents, are able to counteract host defence mechanisms and wound healing processes to facilitate blood-feeding. Cutting the epidermis by the tick chelicerae and penetration of the hypostome into the dermis followed by feeding elicit a wound healing response, involving coagulation, inflammation, angiogenesis, synthesis of extracellular matrix and ground substances, as well as tissue remodelling. These repair… CONTINUE READING

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