Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignancies.

  title={Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignancies.},
  author={Charles Dumontet and Mary Ann Jordan and Francis Y. F. Lee},
  journal={Molecular cancer therapeutics},
  volume={8 1},
Microtubule-targeting agents, such as taxanes and epothilones, block mitosis and cell proliferation by targeting the dynamics of the cytoskeleton. The taxanes are widely used for treatment of various malignancies, but primary and acquired resistance to chemotherapy remains a significant clinical concern. Class I, II, III, IV, and V beta-tubulin isotypes are expressed in human tumors. Overexpression of the betaIII-tubulin isotype is one mechanism that can render tumor cells resistant to taxanes… CONTINUE READING
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