Ivermectin is better than benzyl benzoate for childhood scabies in developing countries

@article{Brooks2002IvermectinIB,
  title={Ivermectin is better than benzyl benzoate for childhood scabies in developing countries},
  author={Parker A. Brooks and Robert Grace},
  journal={Journal of Paediatrics and Child Health},
  year={2002},
  volume={38}
}
Objective:  To compare single dose oral ivermectin with topical benzyl benzoate for the treatment of paediatric scabies. 

A prospective cohort of patients with common scabies treated with 10% benzyl benzoate emulsion as monotherapy: EPIGALE study

No recent data in real‐life are available on the efficacy and safety of 10% benzyl benzoate emulsion for skin application administered as monotherapy.

Scabies and pediculosis pubis: an update of treatment regimens and general review.

  • P. Leone
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
The present article dissects the epidemiological profile and treatment of both Sarcoptes scabiei variant hominis and pediculosis pubis.

European guideline for the management of scabies, 2010

Transmission of the mite Sarcoptes scabiei generally occurs by protracted direct body contact; although in crusted scabies, transmission also occurs via infected clothing or bedding. Diagnosis is

Efficacy and tolerability of a new synergized pyrethrins thermofobic foam in comparison with benzyl benzoate in the treatment of scabies in convicts: the ISAC study (Studio Della scabbia in ambiente carcerario)

A multicentre, randomized, comparative, parallel group, investigator‐blinded trial to evaluate the efficacy and tolerability of synergized pyrethrins foam (PF) in comparison with benzyl benzoate (BB) lotion.

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial.

Topical BB was clearly more effective than oral IV for treating scabies in a Senegalese community, and early study cessation was prompted by clear findings.

Comparative study of oral ivermectin, topical permethrin and benzyl benzoate in the treatment of scabies

Oral ivermectin may serve a good alternative for managing scabies under certain conditions like poor compliance to topical scabicides and topical benzyl benzoate.

European guideline for the management of scabies

  • G. Scott
  • Biology
    International journal of STD & AIDS
  • 2001
Mites are capable of burrowing into the stratum corneum of a contact person within one hour, and Hypersensitivity to proteases in mite faecal matter generates both local and distant hypersensitivity reactions.

Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients.

Compared with topical benzyl benzoate and monosulfiram in the treatment of scabies, ivermectin was at least as effective and led to more rapid improvement.

Scabies community prevalence and mass drug administration in two Fijian villages

This work estimated scabies prevalence and compared the efficacy and tolerability of mass drug administration of benzyl benzoate lotion (BB) or oral ivermectin (IVM) in two villages in Fiji.

The efficacy of topical and oral ivermectin in the treatment of human scabies.

Ivermectin is an effective and cost-comparable alternative to topical agents in the treatment of scabies infection and in comparison to other medications such as lindane, benzyl benzoate, crotamiton and malathion, ivermECTin was more effective in the Treatment ofScabies.
...

References

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This open‐label study investigated the therapeutic effect and adverse reactions of oral ivermectin in scabies patients and found it to be safe and effective in patients with scabies.

Crusted scabies in two immunocompromised children: Successful treatment with oral ivermectin

Two immunodeficient children, aged 4 and 12 years, with crusted scabies were successfully treated with a single oral dose of ivermectin (200 μg/kg), showing an excellent therapeutic response and absence of side‐effects.

Comparison of ivermectin and benzyl benzoate for treatment of scabies.

The results show that oral ivermectin is a valuable alternative to benzyl benzoate local treatment and was greater in the group IVER at day 7, 14 and 30, but the difference was not statistically significant.

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The authors report six new cases of patients suffering from severe infestation with the mite sarcoptes scabiei, treated with ivermectin, currently the only oral therapy available for this disease, which was very effective in all cases.

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To study the efficacy of ivermectin for scabies, a trial with this drug that could be easily administered, with fast application and high efficacy, was undertaken and found that all patients were cured, tolerated the medication well, and there were no side effects or signs of recurrence 2, 4, or 6 weeks after therapy.

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Given the expanding use of ivermectin for scabies, we would like to make a few points in its applicability to pediatric patients. First, we need some background. Ivermectin has been used in

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