Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro.

@article{Vatta2014IvermectindependentAO,
  title={Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro.},
  author={Adriano F. Vatta and Michael T. Dzimianski and Bob E. Storey and Melinda S. Camus and Andrew R. Moorhead and Ray M. Kaplan and Adrian J Wolstenholme},
  journal={Veterinary parasitology},
  year={2014},
  volume={206 1-2},
  pages={
          38-42
        }
}
The macrocyclic lactones are the only anthelmintics used to prevent heartworm disease, but it is very difficult to reproduce their in vivo efficacy against Dirofilaria immitis larvae in experiments in vitro. These assays typically measure motility, suggesting that paralysis is not the mode of action of the macrocyclic lactones against D. immitis. We isolated peripheral blood mononuclear cells (PBMC) and neutrophils from uninfected dogs and measured their adherence to D. immitis microfilariae in… CONTINUE READING
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