Ivermectin: An Anthelmintic, an Insecticide, and Much More.

@article{Martin2020IvermectinAA,
  title={Ivermectin: An Anthelmintic, an Insecticide, and Much More.},
  author={Richard J. Martin and Alan P Robertson and Shivani Choudhary},
  journal={Trends in parasitology},
  year={2020}
}
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to reposition ivermectin for the treatment of other diseases that are not caused by helminth and insect parasites. The standard theory of its anthelmintic and insecticidal mode of action is that it is a selective positive allosteric modulator of glutamate-gated chloride channels found in nematodes and insects. At higher concentrations, ivermectin also acts as an… Expand
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