Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

  title={Ivabradine, coronary artery disease, and heart failure: beyond rhythm control},
  author={Pietro Scicchitano and Francesca Cortese and Gabriella Ricci and Santa Carbonara and Michele Moncelli and Massimo Iacoviello and Annagrazia Cecere and Michele Gesualdo and Annapaola Zito and Pasquale Caldarola and Domenico Scrutinio and Rocco Lagioia and Graziano Riccioni and Marco Matteo Ciccone},
  booktitle={Drug design, development and therapy},
Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce… CONTINUE READING
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