Itraconazole resistance in Aspergillus fumigatus.

  title={Itraconazole resistance in Aspergillus fumigatus.},
  author={David William Denning and Kanamarlapudi Venkateswarlu and Kath Oakley and Michael J. Anderson and Nigel J. Manning and David A Stevens and David W. Warnock and Steven L Kelly},
  journal={Antimicrobial agents and chemotherapy},
  volume={41 6},
Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumigatus to itraconazole correlated with in vivo outcome has not been previously described. For three isolates (AF72, AF90, and AF91) of A. fumigatus from two patients with invasive… CONTINUE READING
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Defective sterol 5,6 desaturase as a cause of azole resistance in Ustilago maydis

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