Itraconazole is an orally active triazole antifungal agent

Abstract

dicated for the treatment of blascomycosis, histoplasmosis, aspergillosis, oropharynea and esophageal candidiases. It is a weak base with a pKa of 3.7 and a low aqueous solubility (,5 mg/ml). Studies have shown that the dissolution and absorption of itraconazole is pH-dependent, with higher serum levels being obtained at lower gastric pH levels. When taken… (More)

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