Itraconazole inhibits HMEC-1 angiogenesis.

  title={Itraconazole inhibits HMEC-1 angiogenesis.},
  author={Renata Del Carratore and Angelo Carpi and Pascale Beffy and Valter Lubrano and Lucia Giorgetti and Bianca Elena Maserti and Maria Annunziata Carluccio and Marcella Simili and Giorgio Iervasi and Silvana Balzan},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  volume={66 4},
Abnormal angiogenesis is implicated in a number of human diseases and endothelial growth inhibition represents a common approach in tumor therapy. Recently itraconazole, frequently used in humans as antifungal drug, which blocks the biosynthesis of cholesterol, has been found to be antiangiogenic in primary umbilical vein endothelial cells. However, the exact antiangiogenic mechanisms remain largely unknown. In this paper, we studied the effect of itraconazole in human dermal microvascular… CONTINUE READING
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