Itraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy.


ISSUES Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. APPROACH AND KEY FINDINGS: This case report highlights the risk of torsade de pointes, a life-threatening cardiac arrhythmia, in a heroin-dependent patient receiving methadone… (More)
DOI: 10.1111/j.1465-3362.2009.00128.x