Itraconazole in the treatment of basal cell carcinoma: A case‐based review of the literature

@article{Ip2021ItraconazoleIT,
  title={Itraconazole in the treatment of basal cell carcinoma: A case‐based review of the literature},
  author={Ken Hiu-Kan Ip and K J McKerrow},
  journal={Australasian Journal of Dermatology},
  year={2021},
  volume={62}
}
  • K. Ip, K. McKerrow
  • Published 23 June 2021
  • Medicine
  • Australasian Journal of Dermatology
Itraconazole is as an anti‐fungal agent with the ability to inhibit the Hedgehog signalling pathway, which makes it a candidate drug that can be repurposed for the treatment of basal cell carcinomas (BCCs). We present a case of metastatic BCC, treated with oral itraconazole 100 mg twice daily, that resulted in sustained partial regression of metastatic pulmonary nodules. A systematic review on the clinical outcomes of BCCs treated with itraconazole highlights that current evidence for its… 
Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma
  • Neha Gupta, E. Ruiz
  • Medicine
    Drug Design, Development and Therapy
  • 2022
TLDR
Treatment of locally advanced basal cell carcinomas requires a multi-disciplinary approach where different modalities including surgery, radiation therapy, Hedgehog Pathway Inhibitors, and immunotherapy can be considered.
DDDT_A_325852 183..190
Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Jamaica Plain, MA, USA Abstract: Basal cell carcinoma (BCC) is the most common cancer in Caucasians, and its incidence

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