Itraconazole for the treatment of histoplasmosis and blastomycosis.

  title={Itraconazole for the treatment of histoplasmosis and blastomycosis.},
  author={Julie Mangino and Peter G. Pappas},
  journal={International journal of antimicrobial agents},
  volume={5 4},
Itraconazole is a triazole compound with broad-spectrum antifungal activity which includes the pathogenic yeasts, certain Aspergillus species, and the endemic fungi such as Histoplasma capsulatum and Blastomycosis dermatitidis. Although prospective trials comparing itraconazole to other azoles and amphotericin B are unavailable, recently published data suggest that itraconazole is the drug of choice for patients with mild to moderate histoplasmosis and blastomycosis without central nervous… CONTINUE READING