Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin.

Abstract

OBJECTIVE To study the disposition of single doses of phenytoin and itraconazole when administered alone and after chronic treatment with the other drug. METHODS Healthy male volunteers were randomized to two groups and studied in parallel. In group 1, a single 200 mg oral dose of itraconazole was administered on two occasions (alone and after 15 days of… (More)

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@article{Ducharme1995ItraconazoleAH, title={Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin.}, author={Maria P Ducharme and Robert L. Slaughter and Larry Warbasse and Pranatharthi H Chandrasekar and Veerle Van De Velde and Geert S J Mannens and David J. Edwards}, journal={Clinical pharmacology and therapeutics}, year={1995}, volume={58 6}, pages={617-24} }