Itk Functions to Control Actin Polymerization at the Immune Synapse through Localized Activation of Cdc42 and WASP

@article{Labno2003ItkFT,
  title={Itk Functions to Control Actin Polymerization at the Immune Synapse through Localized Activation of Cdc42 and WASP},
  author={Christine M. Labno and Carol M. Lewis and Daoqi You and Daisy W Leung and Ana Takesono and Natalie Kamberos and Abhinav Seth and Lisa D. Finkelstein and Michael K Rosen and Pamela L Schwartzberg and Janis K Burkhardt},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1619-1624}
}
Actin polymerization at the immune synapse is required for T cell activation and effector function; however, the relevant regulatory pathways remain poorly understood. We showed previously that binding to antigen presenting cells (APCs) induces localized activation of Cdc42 and Wiskott-Aldrich Syndrome protein (WASP) at the immune synapse. Several lines of evidence suggest that Tec kinases could interact with WASP-dependent actin regulatory processes. Since T cells from Rlk-/-, Itk-/-, and Rlk… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 32 references

Contingent phosphorylation / 3 domain ligands

  • E. Torres, M. K. Rosen
  • J . Biol . Chem .
  • 2003

Phos - Aldrich syndrome protein by Lyn and Btk is regulated by CDC 42 . phorylation of tyrosine 291 enhances the ability of WASp toFEBS

  • G. O. Cory, R. Garg, R. Cramer, A. J. Ridley
  • Lett .
  • 2002

Phosphorylation of the linker for activation of T-cells

  • S. katesan, K. O’Day, G. L. Schieven, T. A. Lin, S. B. Kanner
  • 2002

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