Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield.

@article{Lewis2016IterativeSO,
  title={Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield.},
  author={James E M Lewis and Joby Winn and Luca Cera and Stephen Michael Goldup},
  journal={Journal of the American Chemical Society},
  year={2016},
  volume={138 50},
  pages={16329-16336}
}
We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of… CONTINUE READING