Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks

@inproceedings{Peng2012IterationMF,
  title={Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks},
  author={Wei Peng and Jianxing Wang and Weiping Wang and Qing Liu and Fang-Xiang Wu and Yi Pan},
  booktitle={BMC Systems Biology},
  year={2012}
}
Identification of essential proteins plays a significant role in understanding minimal requirements for the cellular survival and development. Many computational methods have been proposed for predicting essential proteins by using the topological features of protein-protein interaction (PPI) networks. However, most of these methods ignored intrinsic biological meaning of proteins. Moreover, PPI data contains many false positives and false negatives. To overcome these limitations, recently many… CONTINUE READING
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