Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5′-guanidinonaltrindole and the biased kappa opioid receptor agonist 6′-guanidinonaltrindole in mice
@inproceedings{Cowan2021ItchinglikeBA, title={Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5′-guanidinonaltrindole and the biased kappa opioid receptor agonist 6′-guanidinonaltrindole in mice}, author={Alan Cowan and Lee-Yuan Liu-Chen and Saadet Inan}, year={2021} }
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References
SHOWING 1-10 OF 40 REFERENCES
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus
- BiologyNeuropharmacology
- 2015
Impact of Pharmacological Manipulation of the κ-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2019
This study shows that the κ-receptor system is involved in an ethologically relevant measure of anhedonia, and that λ-selective doses of these antagonists can produce effects consistent with rapid anti-anhedonia.
Kappa opioid antagonist effects of the novel kappa antagonist 5′-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys
- Biology, PsychologyPsychopharmacology
- 2002
Results suggest that 5′-Guanidinonaltrindole is a potent and selective kappa antagonist with a slow onset and long duration of action in rhesus monkeys.
Investigation of gastrin-releasing peptide as a mediator for 5′-guanidinonaltrindole-induced compulsive scratching in mice
- Biology, ChemistryPeptides
- 2011
Nalfurafine prevents 5′-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5′-guanidinonaltrindole-elicited scratching behavior in mice
- BiologyNeuroscience
- 2009
Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice
- Biology, PsychologyNeuropharmacology
- 2015
Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects.
- BiologyACS chemical neuroscience
- 2020
Pharmacology of compound 42B, a 3-dehydroxy analog of nalfurafine, is characterized and it is suggested that among the KOR-induced adverse behaviors, CPA can be separated from motor incoordination and hypolocomotion.
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice
- BiologyNeuroscience Letters
- 2014
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence
- Biology, PsychologyNeuropsychopharmacology
- 2018
Overall, these studies demonstrate that effects of 10 mg Opra Kappa are largely consistent with those predicted for a selective KOP-r antagonist, and is therefore feasible for further studies in cocaine-dependent persons.
Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.
- Biology, ChemistryEuropean journal of pharmacology
- 2001