Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice
@article{Yamaguchi1999ItchassociatedRI, title={Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice}, author={Tomomi Yamaguchi and Tetsuro Nagasawa and Masamichi Satoh and Yasushi Kuraishi}, journal={Neuroscience Research}, year={1999}, volume={35}, pages={77-83} }
185 Citations
Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids
- Biology, MedicineArchives of Dermatological Research
- 2018
It is shown that intradermal and intraperitoneal administration of sumatriptan significantly reduce 5-HT-induced scratching behavior in mice, and combined treatment with sub-effective doses of sum atriptan and an opioid receptor antagonist, naltrexone, decreases 5- HT-evoked scratching responses.
5‐HT3 receptors antagonists reduce serotonin‐induced scratching in mice
- Biology, MedicineFundamental & clinical pharmacology
- 2015
It is shown that the scratching induced by intradermal serotonin is mediated by 5‐HT3 receptors subtype, which means that 5-HT3 may play a role in mediating serotonin‐associated itch responses, and 5‐ HT3 receptors as possible targets for antipruritic agents are introduced.
5-Hydroxytryptamine (5-HT)2 Receptor Involvement in Acute 5-HT-Evoked Scratching but Not in Allergic Pruritus Induced by Dinitrofluorobenzene in Rats
- BiologyJournal of Pharmacology and Experimental Therapeutics
- 2003
Intradermal injection of α-methylserotonin, a 5-HT2 receptor agonist, elicited scratching behavior in a dose-dependent manner, indicating that acute5-HT-induced scratching is mediated via peripheral 5- HT2 receptors.
Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.
- Biology, MedicineThe Journal of investigative dermatology
- 2004
The results suggest that nociceptin acts on ORL1 receptor on the keratinocytes to produce leukotriene B(4), which induces itch-associated responses in mice.
Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice.
- Biology, MedicineBiological & pharmaceutical bulletin
- 2008
It is suggested that mu-opioid receptor in the lower brainstem, but not spinal cord, is a site of central pruritogenic action of opioids and is involved in the facilitatory regulation of itch signaling.
Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice.
- Biology, ChemistryJournal of pharmacological sciences
- 2010
Results suggest that leukotriene B(4) receptor and M(3) muscarinic acetylcholine receptor are involved in the itch-associated response induced by repeated application of oxazolone in mice.
Serotonin Receptor 2B Mediates Mechanical Hyperalgesia by Regulating Transient Receptor Potential Vanilloid 1
- BiologyJournal of Molecular Neuroscience
- 2015
5-HT2B mediates 5-HT-induced mechanical hyperalgesia by regulating TRPV1 function through the Gq/11-phospholipase Cβ-protein kinase Cε pathway mediated by 5- HT2B.
Intradermal cholinergic agonists induce itch-associated response via M3 muscarinic acetylcholine receptors in mice.
- BiologyJapanese journal of pharmacology
- 2002
Muscarinic agonists are suggested to produce itch through activation of M3 muscarinic receptors in the skin throughactivation of M2 muscaric receptors inThe skin.
Clonidine inhibits itch-related response through stimulation of α(2)-adrenoceptors in the spinal cord in mice.
- Biology, MedicineEuropean journal of pharmacology
- 2011
Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice.
- BiologyEuropean journal of pharmacology
- 2008
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