Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice

@article{Yamaguchi1999ItchassociatedRI,
  title={Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice},
  author={Tomomi Yamaguchi and Tetsuro Nagasawa and Masamichi Satoh and Yasushi Kuraishi},
  journal={Neuroscience Research},
  year={1999},
  volume={35},
  pages={77-83}
}
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185 Citations
Highly Influential Citations
8
Background Citations
59
Methods Citations
4
Results Citations
8

185 Citations

Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids

It is shown that intradermal and intraperitoneal administration of sumatriptan significantly reduce 5-HT-induced scratching behavior in mice, and combined treatment with sub-effective doses of sum atriptan and an opioid receptor antagonist, naltrexone, decreases 5- HT-evoked scratching responses.

5‐HT3 receptors antagonists reduce serotonin‐induced scratching in mice

It is shown that the scratching induced by intradermal serotonin is mediated by 5‐HT3 receptors subtype, which means that 5-HT3 may play a role in mediating serotonin‐associated itch responses, and 5‐ HT3 receptors as possible targets for antipruritic agents are introduced.

Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.

The results suggest that nociceptin acts on ORL1 receptor on the keratinocytes to produce leukotriene B(4), which induces itch-associated responses in mice.

Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice.

It is suggested that mu-opioid receptor in the lower brainstem, but not spinal cord, is a site of central pruritogenic action of opioids and is involved in the facilitatory regulation of itch signaling.

Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice.

Results suggest that leukotriene B(4) receptor and M(3) muscarinic acetylcholine receptor are involved in the itch-associated response induced by repeated application of oxazolone in mice.

Intradermal cholinergic agonists induce itch-associated response via M3 muscarinic acetylcholine receptors in mice.

Muscarinic agonists are suggested to produce itch through activation of M3 muscarinic receptors in the skin throughactivation of M2 muscaric receptors inThe skin.

Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin

Clonidine inhibits itch-related response through stimulation of α(2)-adrenoceptors in the spinal cord in mice.

Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice.

Cathepsin E induces itch-related response through the production of endothelin-1 in mice.

...

References

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The results suggest that scratching of the mouse induced by an i.d. injection of SP is itch-associated response, and the SP action may be mediated at least partly by cutaneous NK1 receptors, and mast cells may not be key factors in SP-induced itching.

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