Itch and pruritus: what are they, and how should itches be classified?

@article{Bernhard2005ItchAP,
  title={Itch and pruritus: what are they, and how should itches be classified?},
  author={Jeffrey D. Bernhard},
  journal={Dermatologic Therapy},
  year={2005},
  volume={18}
}
  • J. Bernhard
  • Published 1 July 2005
  • Philosophy
  • Dermatologic Therapy
ABSTRACT:  Itch and pruritus are two terms for the same thing. In this essay I will argue that casting about for a distinction between them creates only confusion. Once that matter is settled, it is still necessary to come up with a clinical classification for itches of different types. No system yet proposed, including the one that will be suggested here, is perfect. 
Pruritus: Progress toward Pathogenesis and Treatment
TLDR
This review summarizes the updated pathogenesis and therapeutic strategies for pruritus and suggests that, apart from histamine, many mediators and signaling pathways are involved in the pathogenesis ofPruritus.
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Application of the redefined clinical classification, newly defined clinical algorithms and inquiry of clinical characteristics of pruritus is helpful in finding the underlying disease.
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The proposed clinical classification of pruritus is oriented at the clinical appearance of the patients and differentiates between disorders with or without primary or secondary skin lesions.
Evaluation of chronic pruritus in older patients
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A rational work-up adapted to the special premises and needs of geriatric patients is presented, which may facilitate the choice of suitable therapeutic regimens.
Systemic Immunosuppressants in the Treatment of Pruritus
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Itch is propagated by complex mechanisms located both peripherally and within the central nervous system, and traditional systemic treatments have limited efficacy and new options are emerging slowly.
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TLDR
The principle difference between diagnoses of chronic pruritus and delusional infestation appears to lie in the patient's interpretation of the cause of the symptoms, rather than underlying physiological differences.
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Background  Pruritus is the most frequent and distressing symptom associated with dermatoses and various internal and neurological diseases.
Chronic pruritus: clinics and treatment.
TLDR
New insights into the underlying pathogenesis ofPruritus have enabled novel treatment approaches that target the pruritus-specific pathophysiological mechanism, and for example, neurokinin-1 antagonists have been found to relieve chronic Pruritus.
Postburn pruritus: A practical review
TLDR
Current evidence supports the use of gabapentin/pregabalin in patients with moderate to severe postburn pruritus as the first line, even if as an "off label" indication.
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