Itch and pruritus: what are they, and how should itches be classified?

@article{Bernhard2005ItchAP,
  title={Itch and pruritus: what are they, and how should itches be classified?},
  author={Jeffrey D. Bernhard},
  journal={Dermatologic Therapy},
  year={2005},
  volume={18}
}
  • J. Bernhard
  • Published 1 July 2005
  • Philosophy
  • Dermatologic Therapy
ABSTRACT:  Itch and pruritus are two terms for the same thing. In this essay I will argue that casting about for a distinction between them creates only confusion. Once that matter is settled, it is still necessary to come up with a clinical classification for itches of different types. No system yet proposed, including the one that will be suggested here, is perfect. 

Pruritus: Progress toward Pathogenesis and Treatment

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This review summarizes the updated pathogenesis and therapeutic strategies for pruritus and suggests that, apart from histamine, many mediators and signaling pathways are involved in the pathogenesis ofPruritus.

Pruritus in palliative care: Getting up to scratch.

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A 75-year-old woman who has end-stage renal disease and is receiving hemodialysis 3 times a week has had mild pruritus for a long time, but recently it has been worse.

Assessing Treatment of Pruritic Scalp

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The divergent responses in this study underlines that there are probably different factors and trigger points which elicit the condition, and more studies on this entity are warranted.

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Application of the redefined clinical classification, newly defined clinical algorithms and inquiry of clinical characteristics of pruritus is helpful in finding the underlying disease.

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The proposed clinical classification of pruritus is oriented at the clinical appearance of the patients and differentiates between disorders with or without primary or secondary skin lesions.

Evaluation of chronic pruritus in older patients

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A rational work-up adapted to the special premises and needs of geriatric patients is presented, which may facilitate the choice of suitable therapeutic regimens.

Systemic Immunosuppressants in the Treatment of Pruritus

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Itch is propagated by complex mechanisms located both peripherally and within the central nervous system, and traditional systemic treatments have limited efficacy and new options are emerging slowly.

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The role of itch fibres and their response to various mediators of pruritus including histamine, vasoactive intestinal peptide, calcitonin gene-related peptide (CGRP), and substance P (SP), and opioids are reviewed.

Delusional Infestation and Chronic Pruritus: A Review.

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TLDR
The principle difference between diagnoses of chronic pruritus and delusional infestation appears to lie in the patient's interpretation of the cause of the symptoms, rather than underlying physiological differences.

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TLDR
Treatments for neuropathic itch are transcranial magnetic stimulation of the brain, new topical cannabinoid receptor agonists, various modes of acupuncture, a holistic approach with healing touch, and cell transplantation to the spinal cord.
...

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