Itch and brain

  title={Itch and brain},
  author={Hideki Mochizuki and Ryusuke Kakigi},
  journal={The Journal of Dermatology},
Itch is an unpleasant somatic sensation that evokes the urge to scratch. Chronic itch is a severe problem that diminishes quality of life. There are many patients suffering from chronic itch across the world. The brain is the final terminal to receive itch‐related signals from the body and plays an important role in perceiving the itch sensation. Thus, to understand the cerebral mechanism of itch perception and how this mechanism differs between healthy subjects and chronic itch patients is… Expand
8 Citations
Differential roles of prelimbic and anterior cingulate cortical region in the modulation of histaminergic and non-histaminergic itch
This study provided direct evidence of Prl involvement in itch modulation and revealed the differential roles of caudal ACC and Prl in regulating histaminergic and non-histaminergic itch. Expand
Assessment of the impact of sex in intensity, skin flares and central processing of histaminergic itch—A pilot study
Itch is the commonest skin‐related symptom, and sex differences are increasingly recognised as important determinants in stratified medicine, but only little is known about sex differences in itch.Expand
Increased grey matter volume and associated resting-state functional connectivity in chronic spontaneous urticaria: A structural and functional MRI study.
The findings indicate that patients suffering from chronic itching conditions, such as CSU, are likely to demonstrate altered GM volume in some brain regions associated with cognitive function. Expand
Functional magnetic resonance imaging in dermatology: The skin, the brain and the invisible
A review looks back to the beginnings of functional neuroimaging in dermatology, summarises the currently available dermatology‐related fMRI studies and discusses the potential future role of fMRI as a stratifying tool in clinical dermatology and in the development of novel therapies. Expand
Gender Differences in the Association of Brain Gray Matter and Pain-Related Psychosocial Characteristics.
Gray matter morphology relates differently to psychosocial characteristics in women and men and provides ideas for further research to investigate if targeting perceived negative consequences of the illness, perceived emotional representations, perceived chronicity, and pain catastrophizing in women, and perceived personal control of the illnesses and kinesiophobia in men, could contribute to the normalization of brain alterations in people with nonspecific chronic spinal pain. Expand
Itch in Atopic Dermatitis.
Exploring itch pathways and mechanisms may lead to novel therapeutic approaches for atopic itch. Expand
In the new DSM-V, skin-picking disorder has been included in the diagnostic system as an independent disorder and describes the self-injury of the skin by picking or scratching with an underlying emotional disorder. Expand
Use of a mechanical brush by dairy cows with chorioptic mange
Assessment of changes in dairy cow motivation to use a brush in relation to signs of mange, and before and after the application of an anti-parasitic drug, indicates that brush use in mange-affected cows decreases after initial usage, and that regardless of the severity of mane, access to a grooming device is a valuable resource for dairy cows. Expand


The cerebral representation of scratching-induced pleasantness.
This study is the first to identify networks activated by scratching-induced pleasantness, and provides important information on the cerebral mechanisms underlying why scratching itchy skin evokes pleasurable feelings that reinforce scratching behaviors. Expand
Neural correlates of perceptual difference between itching and pain: A human fMRI study
FMRI time series analysis demonstrates that the difference in the sensitivity of PCC, the posterior insula and the thalamus between itching and pain would be responsible for the perceptual difference between these sensations. Expand
Neural basis of contagious itch and why some people are more prone to it
This study established that the social contagion of itch is essentially a normative response (experienced by most people), and that the degree of contagion is related to trait differences in neuroticism (i.e., the tendency to experience negative emotions), but not to empathy. Expand
The brain circuitry mediating antipruritic effects of acupuncture.
Greater itch reduction following acupuncture was associated with greater reduction in putamen response, a region implicated in motivation and habitual behavior underlying the urge to scratch, specifically implicating this region in acupuncture's antipruritic effects. Expand
Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.
The patterns of itch-induced activation reported here may help explain why chronic itch sufferers frequently self-harm through uncontrollable itch-scratch cycles. Expand
Cortico-subcortical activation patterns for itch and pain imagery
Findings indicate that brain regions associated with imagery of itch are the same as those involved in imagery of pain, but their functional networks differ, which may explain why motor responses to itch are more socially contagious than those related to pain. Expand
Evoked itch perception is associated with changes in functional brain connectivity
The results provide the first evidence of itch-dependent changes in functional connectivity across multiple brain regions and suggest that greater interaction between nodes of this executive attention network serves to limit itch sensation via enhanced top-down regulation. Expand
Brain activation by histamine prick test-induced itch.
Itch is a well-known dermatological symptom whose reactions in the brain have been studied very less, and brain responses to longer-lasting histamine reaction in healthy participants were tested. Expand
Brain’s Reward Circuits Mediate Itch Relief. A Functional MRI Study of Active Scratching
A significant involvement of the reward system including the ventral tegmentum of the midbrain, coupled with a mechanism deactivating the periaqueductal gray matter suggests that itch modulation operates in reverse to the mechanism known to suppress pain. Expand
Imaging of central itch modulation in the human brain using positron emission tomography
Findings indicate that the modified brain activities in the PAG, the cingulate, the frontal and the parietal cortex might be associated with the itch modulation in the central nervous system and that the S2 might not be primarily involved in processing the itching perception in the brain since the activity of S2 was not observed in any concentration of itching stimuli. Expand