author={Gil Yosipovitch and Malcolm W. Greaves and Martin Schmelz},
  journal={The Lancet},
Introduction to the Pharmacology and Physiology of Itch Studies with microelectrodes and with plant spicules containing potent itch-producing proteolytic enzymes demonstrated that itch receptors are a plexus of free nerve endings closely related to the dermo-epidermal zone. The receptors are stimulated by mediators, including histamine, released in inflamed itchy skin. Certain mediators, although not capable of causing itching alone, can potentiate the action of other itch-producing agents… 
Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1)
The molecular mechanism of the effects of riboflavin on histamine-dependent itch is investigated based on behavioral tests and electrophysiological experiments and suggests that it might be a useful drug for the treatment of Histamine- dependent itch.
Chapter 18 Itch and cold allodynia.
  • M. Schmelz
  • Biology
    Handbook of clinical neurology
  • 2006
Conopeptides promote itch through human itch receptor hMgprX1
Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice
Results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.
Affective Touch Reduces Electrically Induced Itch Experience
It is suggested that affective touch, as with acute pain, has a relieving effect on electrically induced itch.
Sex Differences in Scratching Behaviors Induced by Intradermal Injections of Pruritogenic Chemicals in C57BL/6 Mice
Compared the scratching behaviors induced by pruritogenic agents in male and female C57BL/6 mice, results suggested that sex differences occured in histamine-dependent compound 4880-induced and histamines-independent chloroquine-induced itch sensations, but not in Histamine-independent SLIGRL-NH2- induced itch sensation.
The neuropsychophysiology of tingling
The Complexity of Pruritus Requires a Variety of Treatment Strategies
An overview of typical skin and systemic diseases involving pruritus is provided and novel treatment approaches include the H4-receptor pathway, which has been successfully investigated in a recent clinical trial in patients with atopic dermatitis.
Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization.
Chronic sensitization leading to chronic pain and itch is reviewed at both peripheral and central levels to facilitate the development of new therapeutics against both chronic dysesthesias based on the underlying pathophysiology.