Itch E3 Ubiquitin Ligase Positively Regulates TGF-β Signaling to EMT via Smad7 Ubiquitination

@inproceedings{Park2014ItchEU,
  title={Itch E3 Ubiquitin Ligase Positively Regulates TGF-β Signaling to EMT via Smad7 Ubiquitination},
  author={Su-Hyun Park and Eun-Ho Jung and Geun-Young Kim and Byung-Chul Kim and Jae Hyang Lim and Chang-Hoon Woo},
  booktitle={Molecules and cells},
  year={2014}
}
TGF-β regulates pleiotropic cellular responses including cell growth, differentiation, migration, apoptosis, extracellular matrix production, and many other biological processes. Although non-Smad signaling pathways are being increasingly reported to play many roles in TGF-β-mediated biological processes, Smads, especially receptor-regulated Smads (R-Smads), still play a central mediatory role in TGF-β signaling for epithelial-mesenchymal transition. Thus, the biological activities of R-Smads… CONTINUE READING

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Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy.

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