Itch: More than Skin Deep

  title={Itch: More than Skin Deep},
  author={Malcolm W. Greaves and N. Khalifa},
  journal={International Archives of Allergy and Immunology},
  pages={166 - 172}
  • M. Greaves, N. Khalifa
  • Published 1 October 2004
  • Biology, Medicine
  • International Archives of Allergy and Immunology
Recent research in neurophysiology of itch has indicated the existence of itch-dedicated nociceptor neurones. The perception of itch is regulated by tonically inhibitory descending neuronal pathways and nociceptor spinal neuronal circuits. There is at present no convincing evidence of an ‘itch centre’ in the brain. A classification of itch has been proposed, based on neurophysiological considerations, which stresses the importance of neurogenic and neuropathic itch, and assists in differential… 

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