It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.

@article{Viskochil2003ItTT,
  title={It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.},
  author={David Viskochil},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 12},
  pages={1791-3}
}
Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Les cellules granuleuses (Mastzellen) dans les tissus normaux et dans certaines maladies chirurgicales

  • H. Greggio
  • Arch. Med
  • 1911
Highly Influential
3 Excerpts

Drug therapy for neurofibromatosis ?

  • L. M. Coussens, Z Werb
  • Arch . Dermatol .
  • 2002

Similar Papers

Loading similar papers…