It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.

  title={It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.},
  author={David Viskochil},
  journal={The Journal of clinical investigation},
  volume={112 12},
Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could… CONTINUE READING


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