It never rains but it pours

@article{CubillosRuiz2011ItNR,
  title={It never rains but it pours},
  author={Juan R. Cubillos-Ruiz and Jose R. Conejo-Garcia},
  journal={Cell Cycle},
  year={2011},
  volume={10},
  pages={368 - 369}
}
Feature on: Cubillos-Ruiz JR, et al. Oncotarget 2010; 1:329-338. 
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A new subfamily called BT3 is presented, which belongs to the B7/BT family, which consists of three members that exhibit 95% identity and form a monophylogenetic group along with the BT‐related members.
BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation
TLDR
Structural and functional data suggest a role for BTNL2 as a negative costimulatory molecule with implications for inflammatory disease.
Inhibitory B7-family molecules in the tumour microenvironment
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The roles of these B7 molecules in the dynamic interactions between tumours and the host immune system, including their expression, regulation and function in the tumour microenvironment are focused on.
BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation1
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BTNL2-Ig inhibited T cell proliferation and TCR activation of NFAT, NF-κB, and AP-1 signaling pathways and is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity
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These findings provide new insights for the role of BTN3 as an inhibitor of excessive cellular immune responses and the magnitude of the cell surface expression ofBTN3 molecules correlated inversely with lymphocyte activity, suggesting that BTN 3 molecules contribute to the maintenance of the immune system.
A Butyrophilin Family Member Critically Inhibits T Cell Activation
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It is found that butyrophilin-like (BTNL)1 molecule functions to dampen T cell activation and is a critical inhibitory molecule for T cellactivation and immune diseases.
CD277 is a Negative Co-stimulatory Molecule Universally Expressed by Ovarian Cancer Microenvironmental Cells
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It is reported that CD277 is consistently expressed in stromal, as well as tumor cells in the microenvironment of human advanced ovarian carcinoma specimens, both of primary and metastatic origin, and this expression is significantly up-regulated by multiple common tumor microenvironmental signals.
BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell Activation
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Sarcoidosis is associated with a truncating splice site mutation in BTNL2
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A systematic three-stage SNP scan of 16.4 Mb on chromosome 6p21 in as many as 947 independent cases of familial and sporadic sarcoidosis and found that a 15-kb segment of the gene butyrophilin-like 2 (BTNL2) was associated with the disease.
Risk of Ovarian Cancer and Inherited Variants in Relapse-Associated Genes
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It is found that inherited markers in the gene encoding MSL1, part of a complex that modifies the histone H4, may decrease risk of invasive serous ovarian cancer.