It never rains but it pours

  title={It never rains but it pours},
  author={Juan R. Cubillos-Ruiz and Jose R. Conejo-Garcia},
  journal={Cell Cycle},
  pages={368 - 369}
Feature on: Cubillos-Ruiz JR, et al. Oncotarget 2010; 1:329-338. 
Immune modulation by butyrophilins
The contribution of butyrophilins to immune homeostasis is emphasized and the potential of targeting these molecules for therapeutic purposes is discussed.
The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response
The butyrophilin family in mammals has been revisited, using phylogenetic analysis to identify all the family members and the phylogenetic relations among them, and to establish a standard nomenclature.
BTN3A2 Expression in Epithelial Ovarian Cancer Is Associated with Higher Tumor Infiltrating T Cells and a Better Prognosis
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Exploring the fine composition of Camelus milk from Kazakhstan with emphasis on protein components
La presente etude visait a identifier, en explorant la fraction proteique des laits de camelides provenant de plusieurs regions du Kazakhstan, des molecules originales (peptides, proteines)
Lack of correlation of BTNL2 polymorphism and cancer risk in sarcoidosis. BTNL2 and cancer risk in sarcoidosis.
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A common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein
Clear functional consequences of a new deletion CNV (BTNL8_BTNL3-del) with potentially important implication in the human immune system and in inflammatory and proliferative disorders are shown.
The role of lupus susceptibility MHC haplotypes and interferon-alpha in gene regulation
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When contributing as engaged citizens in society, learners need to articulate their ideas clearly, precisely, accurately, and succinctly with the use of connective words. Connective words are linking


Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells
A new subfamily called BT3 is presented, which belongs to the B7/BT family, which consists of three members that exhibit 95% identity and form a monophylogenetic group along with the BT‐related members.
BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation
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Inhibitory B7-family molecules in the tumour microenvironment
The roles of these B7 molecules in the dynamic interactions between tumours and the host immune system, including their expression, regulation and function in the tumour microenvironment are focused on.
BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation1
BTNL2-Ig inhibited T cell proliferation and TCR activation of NFAT, NF-κB, and AP-1 signaling pathways and is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity
These findings provide new insights for the role of BTN3 as an inhibitor of excessive cellular immune responses and the magnitude of the cell surface expression ofBTN3 molecules correlated inversely with lymphocyte activity, suggesting that BTN 3 molecules contribute to the maintenance of the immune system.
A Butyrophilin Family Member Critically Inhibits T Cell Activation
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CD277 is a Negative Co-stimulatory Molecule Universally Expressed by Ovarian Cancer Microenvironmental Cells
It is reported that CD277 is consistently expressed in stromal, as well as tumor cells in the microenvironment of human advanced ovarian carcinoma specimens, both of primary and metastatic origin, and this expression is significantly up-regulated by multiple common tumor microenvironmental signals.
BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell Activation
Data are consistent with a coinhibitory role for mouse BTNs, including BTN1A1, the BTN expressed in the lactating mammary gland and on milk lipid droplets, and the presence of one or more receptors on these cells.
Sarcoidosis is associated with a truncating splice site mutation in BTNL2
A systematic three-stage SNP scan of 16.4 Mb on chromosome 6p21 in as many as 947 independent cases of familial and sporadic sarcoidosis and found that a 15-kb segment of the gene butyrophilin-like 2 (BTNL2) was associated with the disease.
Risk of Ovarian Cancer and Inherited Variants in Relapse-Associated Genes
It is found that inherited markers in the gene encoding MSL1, part of a complex that modifies the histone H4, may decrease risk of invasive serous ovarian cancer.