It is a complex issue: emerging connections between epigenetic regulators in drug addiction
@article{Anderson2018ItIA, title={It is a complex issue: emerging connections between epigenetic regulators in drug addiction}, author={Ethan M Anderson and Rachel D. Penrod and Sarah M. Barry and B. Hughes and M. Taniguchi and C. Cowan}, journal={European Journal of Neuroscience}, year={2018}, volume={50} }
Drug use leads to addiction in some individuals, but the underlying brain mechanisms that control the transition from casual drug use to an intractable substance use disorder (SUD) are not well understood. Gene x environment interactions such as the frequency of drug use and the type of substance used likely to promote maladaptive plastic changes in brain regions that are critical for controlling addiction‐related behavior. Epigenetics encompasses a broad spectrum of mechanisms important for… CONTINUE READING
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References
SHOWING 1-10 OF 230 REFERENCES
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
- Biology, Medicine
- Nature Neuroscience
- 2014
- 147
- PDF
Cellular basis of memory for addiction
- Medicine, Psychology
- Dialogues in clinical neuroscience
- 2013
- 163
- PDF
Dysregulation of Acetylation Enzymes Inanimal Models of Psychostimulant use Disorders: Evolving Stories.
- Medicine
- Current neuropharmacology
- 2016
- 2
- Highly Influential
The Role of Histone Acetylation in Cocaine-Induced Neural Plasticity and Behavior
- Biology, Medicine
- Neuropsychopharmacology
- 2013
- 67
- PDF
Epigenetic landscape of amphetamine and methamphetamine addiction in rodents
- Biology, Medicine
- Epigenetics
- 2015
- 57
- Highly Influential
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
- Biology, Medicine
- Neuron
- 2007
- 534
- Highly Influential
- PDF
Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine
- Medicine
- Science Translational Medicine
- 2011
- 212
- PDF
Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain
- Biology, Medicine
- Neuroscience Letters
- 2011
- 15
- Highly Influential