It is a complex issue: emerging connections between epigenetic regulators in drug addiction

@article{Anderson2018ItIA,
  title={It is a complex issue: emerging connections between epigenetic regulators in drug addiction},
  author={Ethan M. Anderson and Rachel D. Penrod and Sarah M. Barry and Brandon W Hughes and Makoto Taniguchi and Christopher W. Cowan},
  journal={European Journal of Neuroscience},
  year={2018},
  volume={50}
}
Drug use leads to addiction in some individuals, but the underlying brain mechanisms that control the transition from casual drug use to an intractable substance use disorder (SUD) are not well understood. Gene x environment interactions such as the frequency of drug use and the type of substance used likely to promote maladaptive plastic changes in brain regions that are critical for controlling addiction‐related behavior. Epigenetics encompasses a broad spectrum of mechanisms important for… 
View on Wiley
ncbi.nlm.nih.gov
11 Citations
Methods Citations
1

11 Citations

Citation Type

Citation Type

Epigenetic Mechanisms of Opioid Addiction
The histone methyltransferase G9a mediates stress‐regulated alcohol drinking
TLDR
It is shown that chronic intermittent ethanol exposure in male mice reduced both G9a and H3K9me2 levels in the adult NAc, but not dorsal striatum, which suggests that chronic alcohol use produces a NAc‐selective reduction in G 9a levels that serves to limit stress‐regulated alcohol drinking.
Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety
TLDR
Evidence is provided that local AAV-RNAi-mediated knockdown of G9a expression in nucleus accumbens shell (NAcSh) of male rats reduces both addictive-related and anxiety-related behaviors and suggests that regulation of G 9a-influenced gene expression could be a common epigenetic mechanism for co-morbid anxiety and psychostimulant addiction.
Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases
TLDR
Evidence is presented for three-dimensional genome changes in physiological brain function and how its disturbance contributes to psychiatric disorders, and a review of remaining questions and future research directions are discussed.
Histone deacetylase inhibition reduces ventral tegmental area dopamine neuronal hyperexcitability involving AKAP150 signaling following maternal deprivation in juvenile male rats
TLDR
It is suggested that AKAP150 plays a critical role in the regulation of VTA DA neuronal excitability and that HDAC‐mediated targeting of AKAP 150 signaling could normalize VTADA dysfunction following ELS thereby providing novel therapeutic targets for prevention of later life psychopathology.
Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood
Combined molecular, structural and memory data unravel the destructive effect of tramadol on hippocampus
Development of Thiazolidinedione-Based HDAC6 Inhibitors to Overcome Methamphetamine Addiction
TLDR
Compound 6b represents a novel HDAC6-isoform selective inhibitor and demonstrates promising therapeutic potential for the treatment of methamphetamine addiction.
Anxiety, the chicken or the egg of addiction: targeting G9a for the treatment of comorbid anxiety and cocaine addiction
TLDR
Identifying and understanding the shared biological mechanisms that lead to comorbid anxiety and cocaine addiction, irrespective of which comes first, is critical for the identification of new treatments.
Addiction in focus: molecular mechanisms, model systems, circuit maps, risk prediction and the quest for effective interventions
TLDR
This research presents a novel and scalable approach called “Smartphones and Neuroscience” that allows for real-time monitoring of the activity of the brain’s “spatially-spatial checkpoints” during the natural progression of disease.
...
...

References

SHOWING 1-10 OF 230 REFERENCES
Epigenetics, microRNA, and addiction
  • P. Kenny
  • Biology, Psychology
    Dialogues in clinical neuroscience
  • 2014
TLDR
The role for miRNAs in regulating basic aspects of neuronal function is reviewed, and the involvement of mi RNAs in controlling the motivational properties of addictive drugs is also summarized.
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
TLDR
The mechanism linking chromatin dynamics to neurobiological phenomena is investigated by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo and it is found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses.
Dysregulation of Acetylation Enzymes in Animal Models of Psychostimulant use Disorders: Evolving Stories
  • J. Cadet
  • Psychology, Biology
    Current Neuropharmacology
  • 2016
TLDR
A brief overview of observations obtained using some models of psychostimulant administration in rodents is provided and CREB binding protein (CBP), HDAC1, HDAC2, HADC3,HDAC4, and HDAC5 are identified as important players in the acetylation and deacetylation processes that occur after contingent or non-contingent administration of psychOSTimulants.
Cellular basis of memory for addiction
  • E. Nestler
  • Biology, Psychology
    Dialogues in clinical neuroscience
  • 2013
TLDR
Most addiction-related molecular and cellular adaptations involve most of the same brain regions that mediate more classic forms of memory, consistent with the view that abnormal memories are important drivers of addiction syndromes.
Neuroepigenetics and addiction.
The Role of Histone Acetylation in Cocaine-Induced Neural Plasticity and Behavior
TLDR
The evidence demonstrating a key role for chromatin regulation via histone acetylation in cocaine action is critically discussed and an exciting new possibility is the extinction of drug-seeking behavior by manipulation of epigenetic mechanisms.
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Epigenetic landscape of amphetamine and methamphetamine addiction in rodents
TLDR
Recent advances in the comprehension of epigenetic mechanisms underlying amphetamine- or methamphetamine-induced behavioral, transcriptional, and synaptic plasticity are discussed.
Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine
TLDR
It is shown that nicotine alters the brain to make it more susceptible to cocaine’s addicting effects, and it is suggested that interfering with this reprogramming may rein in cocaine abuse.
Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
TLDR
Using conditional mutagenesis and viral-mediated gene transfer, it is found that G9a down-regulation increased the dendritic spine plasticity of nucleus accumbens neurons and enhanced the preference for cocaine, thereby establishing a crucial role for histone methylation in the long-term actions of cocaine.
...
...