It cuts two ways: microtubule loss during Alzheimer disease.

@article{Jean2013ItCT,
  title={It cuts two ways: microtubule loss during Alzheimer disease.},
  author={Daphney C Jean and Peter W. Baas},
  journal={The EMBO journal},
  year={2013},
  volume={32 22},
  pages={2900-2}
}
Microtubule loss from axons and dendrites is a key contributor to nervous system degeneration during Alzheimer disease. Previous evidence suggested a simple pathway by which tau dissociation from microtubules in the axon allows excess severing of microtubules by katanin. Now, new evidence has emerged for a more complex pathway by which abnormal tau invasion into dendrites, triggered by Ab oligomers, results in excess severing of microtubules by spastin. Alzheimer disease (AD) is a member of a… CONTINUE READING
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