Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.

@article{Micheletti2007IstaroximeAS,
  title={Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.},
  author={Rosella Micheletti and Fiorentina Palazzo and Paolo Barassi and G. Giacalone and Mara Ferrandi and Antonio Schiavone and Barbara Moro and Oberdan Parodi and Patrizia Ferrari and Giuseppe Bianchi},
  journal={The American journal of cardiology},
  year={2007},
  volume={99 2A},
  pages={24A-32A}
}
Interventions involving calcium cycling may represent a promising approach to heart failure (HF) therapy because calcium handling is known to be deranged in human and experimental HF. Istaroxime is a sodium-potassium adenosine triphosphatase (ATPase) inhibitor with the unique property of increasing sarcoplasmic reticulum calcium ATPase (SERCA) isoform 2a (SERCA2a) activity. Because this was demonstrated in normal experimental models, we investigated whether istaroxime is able to improve global… CONTINUE READING

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