• Corpus ID: 18940176

Issues relating to the use of BCG in immunization programmes A discussion document

  title={Issues relating to the use of BCG in immunization programmes A discussion document},
  author={Paul E M Fine and Ilona A Carneiro and Julie B. Milstien and C. John Clements},
1 Infectious Disease Epidemiology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England. 2 Scientist, Department of Vaccines and Biologicals, Health Technology and Pharmaceuticals, World Health Organization, 1211 Geneva 27, Switzerland. 3 Medical Officer, Department of Vaccines and Biologicals, Health Technology and Pharmaceuticals,World Health Organization, 1211 Geneva 27, Switzerland. 

Figures and Tables from this paper

Protection by BCG against tuberculosis : a systematic review of randomised controlled trials
This poster presents a poster presented at the 2016 UK Conference on Minority Ethnic Minorities in Medicine and Public Health about the importance of ethnic minority participation in the medical profession and its role in human health.
Vaccines against tuberculosis: A review.
Developing an improved vaccine against tuberculosis
The nature of protective immunity to Mycobacterium tuberculosis and how this relates to the development of new candidate vaccines is considered and the issues surrounding the progression of the most promising candidates into Phase I clinical trials are discussed.
Guidance for National Tuberculosis Programmes on the management of tuberculosis in children CHAPTER 1 IN THE SERIES
Critical areas for further research include a better understanding of the epidemiology of childhood TB, vaccine development, the development of better diagnostic techniques, new drug development, and the optimal formulations and dosing of first- and second-line TB drugs in children.
BCG vaccine and pulmonary tuberculosis
Pulmonary TB is more common than disseminated TB and BCG vaccine has had a minimal effect on the global burden of pulmonary TB, so combined strategies in the field of control and treatment of TB rather than vaccination are necessary.
Does BCG have a role in tuberculosis control and prevention in the United Kingdom?
Questions remain questions as to what role BCG plays in TB control and prevention in the UK.
BCG vaccination: An update on current Australian practices.
The BCG vaccine is most effective at preventing severe disseminated TB disease in young children and has variable efficacy in preventing adult disease, but given the small risk of adverse effects, vaccination should be undertaken by a practitioner experienced in its administration.
Vaccine against tuberculosis: what’s new?
Several vaccines are in the pipeline, but further studies on basic research, clinical trial and mass vaccination campaigns are needed to achieve the TB eradication target by 2050.
Guidance for National Tuberculosis Programmes on the management of tuberculosis in children. Chapter 1: introduction and diagnosis of tuberculosis in children.
  • A. Munthali
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2006
There is an urgent need to improve the diagnosis and management of children with TB, and the prevention of TB in children, by ensuring their inclusion under the implementation of the Stop TB strategy by National TB Programmes.


Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety.
There is no evidence that when administered to newborns different preparations of BCG vaccine exhibit different efficacies, but other factors, including dose, administration technique, and recipient characteristics are also important in determining vaccine-associated reactions.
Protective efficacy of BCG vaccine against leprosy in southern Malaŵi
Findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic, and suggest that smallpox immunization had no effect.
Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis.
An attempt was made to reproduce in guinea pigs what most likely occurs when BCG vaccination is, to lead to the view that vaccination against tuberculosis is a valuable tool in tuberculosis control.
Bacille Calmette-Guérin vaccination for the prevention of tuberculosis in health care workers.
  • T. BrewerG. Colditz
  • Medicine, Political Science
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1995
Although the studies had too many methodological flaws to be combined in a quantitative meta-analysis, they suggest that vaccination with BCG is effective in reducing the incidence of tuberculosis among health care workers.
The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature.
BCG vaccination of newborns and infants significantly reduces the risk of tuberculosis--by over 50%, on average, suggesting that BCG efficacy may persist through 10 years after infant vaccination.
Lymphadenitis associated with BCG vaccination: a report of an outbreak in Harare, Zimbabwe.
A study was undertaken to investigate an outbreak of BCG-associated lymphadenitis in the City of Harare and found that a vaccine strain that is more reactogenic gives better protection but also has a greater risk of complications.