• Corpus ID: 18940176

Issues relating to the use of BCG in immunization programmes A discussion document

@inproceedings{Fine1999IssuesRT,
  title={Issues relating to the use of BCG in immunization programmes A discussion document},
  author={Paul E M Fine and Ilona A Carneiro and Julie B. Milstien and C. John Clements},
  year={1999}
}
1 Infectious Disease Epidemiology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England. 2 Scientist, Department of Vaccines and Biologicals, Health Technology and Pharmaceuticals, World Health Organization, 1211 Geneva 27, Switzerland. 3 Medical Officer, Department of Vaccines and Biologicals, Health Technology and Pharmaceuticals,World Health Organization, 1211 Geneva 27, Switzerland. 
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165 Citations
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Results Citations
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References

SHOWING 1-10 OF 153 REFERENCES
Variation in protection by BCG: implications of and for heterologous immunity
  • P. Fine
  • Biology, Medicine
    The Lancet
  • 1995
Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety.
TLDR
There is no evidence that when administered to newborns different preparations of BCG vaccine exhibit different efficacies, but other factors, including dose, administration technique, and recipient characteristics are also important in determining vaccine-associated reactions.
Protective efficacy of BCG vaccine against leprosy in southern Malaŵi
TLDR
Findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic, and suggest that smallpox immunization had no effect.
Evaluation of the protective effect of BCG vaccination by a case-control study in Yaounde, Cameroon.
Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis.
TLDR
An attempt was made to reproduce in guinea pigs what most likely occurs when BCG vaccination is, to lead to the view that vaccination against tuberculosis is a valuable tool in tuberculosis control.
Bacille Calmette-Guérin vaccination for the prevention of tuberculosis in health care workers.
  • T. BrewerG. Colditz
  • Medicine, Political Science
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1995
TLDR
Although the studies had too many methodological flaws to be combined in a quantitative meta-analysis, they suggest that vaccination with BCG is effective in reducing the incidence of tuberculosis among health care workers.
The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature.
TLDR
BCG vaccination of newborns and infants significantly reduces the risk of tuberculosis--by over 50%, on average, suggesting that BCG efficacy may persist through 10 years after infant vaccination.
Lymphadenitis associated with BCG vaccination: a report of an outbreak in Harare, Zimbabwe.
TLDR
A study was undertaken to investigate an outbreak of BCG-associated lymphadenitis in the City of Harare and found that a vaccine strain that is more reactogenic gives better protection but also has a greater risk of complications.
The protective effect of BCG against Mycobacterium ulcerans disease: a controlled trial in an endemic area of Uganda.
Impact of BCG vaccination programmes in children and young adults on the tuberculosis problem.
...
...