Urology nurse managers and practitioners play a key role in minimizing the risk of infection to patients. It is essential that managers understand the processes of sterilization and disinfection, precautions, recommendations, and related issues to establish appropriate policies and procedures. It is equally important for practitioners to understand sterilization and disinfection and the rationale for practice guidelines. This area is dynamic, with new products and technology being introduced into the market each year. Along with these innovations will be additional information, and possibly revisions in recommendations. Therefore, urology nurses must remain current with scientific literature and national standards.