Issues in Using Human Variability Distributions to Estimate Low-Dose Risk

@inproceedings{Crump2009IssuesIU,
  title={Issues in Using Human Variability Distributions to Estimate Low-Dose Risk},
  author={Kenny S. Crump and Weihsueh A Chiu and Ravi Subramaniam},
  booktitle={Environmental health perspectives},
  year={2009}
}
BACKGROUND The National Research Council (NRC) Committee on Improving Risk Analysis Approaches Used by the U.S. EPA (Environmental Protection Agency) recommended that low-dose risks be estimated in some situations using human variability distributions (HVDs). HVD modeling estimates log-normal distributions from data on pharmacokinetic and pharmacodynamic variables that affect individual sensitivities to the toxic response. These distributions are combined into an overall log-normal distribution… CONTINUE READING

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