Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors.

@article{Barhwal2009IsradipineAH,
  title={Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors.},
  author={Kalpana Kumari Barhwal and Sunil Kumar Hota and Iswar Baitharu and Dipti Prasad and Shashi Bala Singh and Govindasamy Ilavazhagan},
  journal={Neurobiology of disease},
  year={2009},
  volume={34 2},
  pages={230-44}
}
Hypobaric hypoxia leads to cognitive dysfunctions due to increase in intracellular calcium through ion channels. The purpose of this study was to examine the temporal contribution of L-type calcium channels and N-methyl-D-aspartate receptors (NMDARs) in mediating neuronal death in male Sprague Dawley rats exposed to hypobaric hypoxia simulating an altitude of 25,000 ft for different durations. Decreasing exogenous calcium loads by blocking voltage-gated calcium influx with isradipine (2.5 mg kg… CONTINUE READING
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