Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis.

@article{Lyttle1994IsozymespecificGI,
  title={Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis.},
  author={Matthew H. Lyttle and Michael D. Hocker and Hon C. Hui and Charles G Caldwell and D T Aaron and {\AA}sa E.Y. Engqvist-Goldstein and Jeffrey E. Flatgaard and Karin Bauer},
  journal={Journal of medicinal chemistry},
  year={1994},
  volume={37 1},
  pages={189-94}
}
Glutathione-S-transferase (GST) isozyme-selective inhibitors were designed by an empirically guided strategy. In the first phase, literature data were used to select C-terminal modifications which generated maximum variation in the catalytic efficiency (Vmax/Km) for glutathione (GSH) analogs used as substrates with different rat GSTs. Also, on the basis of literature data, the sulfhydryl group was functionalized with a selection of alkyl and aryl groups to maximize potential isozyme specificity… CONTINUE READING

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