Isozyme-selective metabolic intermediate complex formation of guinea pig hepatic cytochrome P450 by N-aralkylated derivatives of 1-aminobenzotriazole.

@article{Sinal1995IsozymeselectiveMI,
  title={Isozyme-selective metabolic intermediate complex formation of guinea pig hepatic cytochrome P450 by N-aralkylated derivatives of 1-aminobenzotriazole.},
  author={Christopher J. Sinal and John Richard Bend},
  journal={Chemical research in toxicology},
  year={1995},
  volume={8 1},
  pages={82-91}
}
The capacity for metabolic intermediate (MI) complex formation as a mechanism of action for the isozyme-selective cytochrome P450 (P450) inhibitors N-benzyl-1-aminobenzotriazole (BBT), N-(alpha-methylbenzyl)-1-aminobenzotriazole (alpha MB), and N-(alpha-ethylbenzyl)-1-aminobenzotriazole (alpha EB) was investigated in hepatic microsomes from untreated, phenobarbital-induced, and beta-naphthoflavone-induced guinea pigs. Similar to other complex forming amines, MI complex formation was observed as… CONTINUE READING